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Dvantages over traditional strategies in terms of safety, stability, ease ofDvantages over traditional strategies in terms of safety, stability, ease of manufacturing, and immunogenicity (Table 1). As DNAbased plasmid vaccines are non-live, non-replicating, non-spreading vaccines, there is a little or no risk of mutation or reversion to the virulent form as with viral vectors, therefore rais
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D proteins may be processed in transfectedWJV|www.wjgnet.comAugust 12, 2015|VolumeD proteins may be processed in transfectedWJV|www.wjgnet.comAugust 12, 2015|Volume 4|Issue 3|Trovato M et al . Vaccine delivery systemsTable 1 Overview of the different vaccine formulationsVaccine type Live attenuated vaccines Description Advantages Disadvantages Immunogenicity Humoral and cytotoxic immune resp
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Heat shock proteinsS(HSPs),2 including molecular chaperones and ATP-dependent proteases. After alleviating stress-induced damage caused by misfolded or unfolded proteins, 32 becomes unstable and is rapidly degraded. However, because excess amounts of HSPs are toxic to the cell, the tight regulation of 32 levels by the degradation machinery is crucial for sustaining growth under any circumstances.
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Dvantages over traditional strategies in terms of safety, stability, ease ofDvantages over traditional strategies in terms of safety, stability, ease of manufacturing, and immunogenicity (Table 1). As DNAbased plasmid vaccines are non-live, non-replicating, non-spreading vaccines, there is a little or no risk of mutation or reversion to the virulent form as with viral vectors, therefore rais
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