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The common repeat sequence: aspartate-serine-serine (DSS) or glutamate-serine-serine (ESS), where the serine is often phosphorylated. An example of such proteins we and others have associated with the mineralization process, are the so-called SIBLING proteins: osteopontin [30,71,72,73], dentin matrix protein 1 [33,74,75], matrix extracellular phosphoglycoprotein [76], bone sialoprotein [77,78] and
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Hinge region of type VII collagen, associated with dystrophic epidermolysis bullosa, is also intrinsically disordered [67]. Additionally, the SIBLING proteins, all IDPs, are also associated with vascular [68,69] and other soft tissue calcifications [70]. Since their genes are expressed in cells associated with these deposits they cannot have accumulated simply due to their affinities for HA or col
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Higher level of psychological stress. The IES-R provides three sub-scores, the mean avoidance, intrusion and hyperarousal scores, a total mean IES-R score (divided by the total number of items) and a total IES-R score (without division by the total number of items). A total IES-R score equal to or more than 33 signifies the likely presence of acute stress reaction syndrome [15,16]. All statistical
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Like sibling children, they share common heritage (genes) and some structural homology, often appearing to play different roles in regulating biomineralization in various states of health and disease of dentin and bone (Table 2). All bind to and regulate cell differentiation via different factors [81]. They all have numerous repeat sequences, most are charged. To illustrate, we developed a PERLbas
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The common repeat sequence: aspartate-serine-serine (DSS) or glutamate-serine-serine (ESS), where the serine is often phosphorylated. An example of such proteins we and others have associated with the mineralization process, are the so-called SIBLING proteins: osteopontin [30,71,72,73], dentin matrix protein 1 [33,74,75], matrix extracellular phosphoglycoprotein [76], bone sialoprotein [77,78] and
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Images. Parameters such as resolution (for time considerations), flip angle (for contrast in the magnitude images) and echo time (for phase contrast) were considered. Vessel wall magnitude and phase measurements: ROIs from the top to the bottom of the visible portions of the femoral artery were taken. The lumen SNR and muscle SNR were calculated on both magnitude and phase images. The contrast-ton
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Larreal-RamirezPagecations and anions [62]; the formation of such chains could also be true of the calcium phosphate prenucleation clusters. 2.2 Pathologic Calcification: Role of IDPs Calcifications occurring in unwanted places ?the aorta, salivary glands and soft tissues, are all associated with IDPs. To illustrate, salivary stones occur when mucins, such as statherin, an un-folded protein [63],
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