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The C-terminal truncated Ex4a(+)WT1 isoform contained the N-terminal transcriptional regulatory area but lacked the zinc finger DNA-binding domain, and so the truncated Ex4a(+)WT1 isoform retained a chance to interact with the transcriptional co-activators but misplaced a chance to bind to promoter of downstream targets. Former reports have proven which the N-terminal domainPLOS 1 | DOI:ten.1371/j
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